Now, let’s dive into the love life of one of the most iconic characters on Grey’s Anatomy: Dr. Alex Karev. Over the years, Alex has had more relationships than a daytime soap opera could dream of. As one of the original surgeons at Grey Sloan Memorial, Alex has gone through quite the romantic journey. From heartbreaks to marriages, and even a few misunderstandings, Alex’s love life has been nothing short of dramatic. Let’s take a trip down memory lane and revisit all the women who have captured the heart of this bad boy turned family man.
Alex Karev and Jo Wilson: A Complicated Love Story
Jo Wilson entered Alex Karev’s life at Miranda Bailey’s wedding during Season 9. Their chemistry was undeniable, and it wasn’t long before Alex admitted his feelings for her. The two began dating, and by the next season, Alex proposed at April Kepner’s wedding. However, Jo wasn’t ready to commit, so they decided to keep dating with the understanding that marriage was in their future. A couple of years later, Alex proposed again, but Jo took her time answering. Things got complicated when Jo revealed she was still married to an abusive husband and was living under a new identity. This revelation put a strain on their relationship.

Alex and Jo on Grey’s Anatomy. (Photo Credit: Getty Images)
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Things got even messier when Alex walked in on Jo and Andrew DeLuca in a compromising situation, assuming they were sleeping together. This led to Alex beating up DeLuca, further damaging his relationship with Jo. At the start of Season 14, Alex revealed to Jo that he had found her abusive husband but decided not to hurt him, proving that he wasn’t inherently violent. Jo eventually forgave him, and the two rekindled their romance. Their journey has been a rollercoaster, but they’re currently happy — at least for now!
Alex Karev and Izzie Stevens: A Love Story Filled with Drama
Alex and Izzie’s relationship began after years of working together as surgical interns at Seattle Grace. Their romance was intense, but it hit a snag when Alex cheated on her with nurse Olivia Harper. They managed to reconcile, but Alex’s insensitive comments about Izzie’s patient, Denny Duquette, caused another rift. Izzie was furious when Alex referred to Denny, who was suffering from heart failure, as a “corpse.” She told him, “Just so we’re clear, we’re over. On your very best day, that ‘corpse’ is twice the man you will ever be. You’re not good enough for me, Alex. You’re not good enough for anyone.”
Despite their breakup, Alex still cared deeply for Izzie. When Denny passed away, Alex helped Izzie cope with the loss, realizing that his feelings for her hadn’t faded. They eventually married in Season 5, but tragedy struck when Izzie’s best friend, George O’Malley, died. This event caused Izzie to leave Alex, and they eventually divorced. Izzie never returned to Seattle, leaving Alex heartbroken once again.
Rebecca Pope (Ava): A Heartbreaking Tale
Alex’s relationship with Rebecca Pope, also known as Ava, began after he rescued her from a ferry accident. She was severely disfigured and pregnant, and Alex helped care for her during her recovery. As they spent more time together, they formed a bond and started dating. Months later, Ava discovered her real identity as Rebecca Pope, a married mother of one, and returned home. However, she continued visiting Alex at the hospital and even claimed she was pregnant with his child.



